解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The naturally antibiotic-resistant bacterium Burkholderia pseudomallei is the causative agent of melioidosis, a disease with stubbornly high mortality and a complex, protracted treatment regimen. The worldwide incidence of melioidosis is likely grossly underreported, though it is known to be highly endemic in northern...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00938-17
更新日期:2018-04-23 00:00:00
abstract::Inbred mouse strains differ in their susceptibility to infection with the facultative intracellular bacterium Listeria monocytogenes, largely due to delayed or deficient innate immune responses. Previous antibody depletion studies suggested that neutrophils (polymorphonuclear leukocytes [PMN]) were particularly import...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00085-18
更新日期:2018-03-22 00:00:00
abstract::Coxiella burnetii is an intracellular pathogen that replicates in a lysosome-derived vacuole. A determinant necessary for C. burnetii virulence is the Dot/Icm type IVB secretion system (T4SS). The Dot/Icm system delivers more than 100 proteins, called type IV effectors (T4Es), across the vacuolar membrane into the hos...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00758-17
更新日期:2018-03-22 00:00:00
abstract::Accurate diagnosis and early treatment of tuberculosis (TB) and latent TB infection (LTBI) are vital to prevent and control TB. The lack of specific biomarkers hinders these efforts. This study's purpose was to screen immunological markers that discriminate Mycobacterium tuberculosis infection outcomes in a setting wh...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00759-17
更新日期:2018-03-22 00:00:00
abstract::Streptococcus pneumoniae is a frequent colonizer of the upper respiratory tract and a leading cause of bacterial pneumonia. The innate immune system senses pneumococcal cell wall components, toxin, and nucleic acids, which leads to production of inflammatory mediators to initiate and control antibacterial defense. Her...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00849-17
更新日期:2018-02-20 00:00:00
abstract::Urinary tract infection (UTI) is the second most common infection in humans, making it a global health priority. Nearly half of all women will experience a symptomatic UTI, with uropathogenic Escherichia coli (UPEC) being the major causative agent of the infection. Although there has been extensive research on UPEC vi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00542-17
更新日期:2018-02-20 00:00:00
abstract::Staphylococcus aureus is a pathogen that causes significant morbidity and mortality. Nasal carriage is a major source of transmission and of endogenous infection. Persistent carriage is detected in ∼30% of healthy individuals. While Th17 cells have been shown to play a role in S. aureus infection and clearance, the im...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00834-17
更新日期:2018-02-20 00:00:00
abstract::Clinical trials of novel tuberculosis (TB) vaccines are expensive, while global resources for TB vaccine development are limited. Therefore, there is a need for robust and predictive preclinical data to support advancement of candidate vaccines into clinical trials. Here, we provide a rationale for using the nonhuman ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00776-17
更新日期:2018-01-22 00:00:00
abstract::Borrelia burgdorferi is a causative agent of Lyme disease, the most common arthropod-borne disease in the United States. B. burgdorferi evades host immune defenses to establish a persistent, disseminated infection. Previous work showed that P66-deficient B. burgdorferi (Δp66) is cleared quickly after inoculation in mi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00186-17
更新日期:2018-01-22 00:00:00
abstract::The opportunistic pathogen Pseudomonas aeruginosa is a major cause of sepsis in severely burned patients. If it is not eradicated from the wound, it translocates to the bloodstream, causing sepsis, multiorgan failure, and death. We recently described the P. aeruginosa heparinase-encoding gene, hepP, whose expression w...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00755-17
更新日期:2017-12-19 00:00:00
abstract::Challenges with the production and suboptimal immunogenicity of malaria vaccine candidates have slowed the development of a Plasmodium falciparum multiantigen vaccine. Attempting to resolve these issues, we focused on the use of highly immunogenic merozoite surface protein 8 (MSP8) as a vaccine carrier protein. Previo...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00486-17
更新日期:2017-12-19 00:00:00
abstract::Streptococcus mutans, a major pathogen of dental caries, is considered one of the causative agents of infective endocarditis (IE). Recently, bacterial DNA encoding 120-kDa cell surface collagen-binding proteins (CBPs) has frequently been detected from S. mutans-positive IE patients. In addition, some of the CBP-positi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00401-17
更新日期:2017-11-17 00:00:00
abstract::Group A streptococci (GAS) are highly prevalent human pathogens whose primary ecological niche is the superficial epithelial layers of the throat and/or skin. Many GAS strains with a strong tendency to cause pharyngitis are distinct from strains that tend to cause impetigo; thus, genetic differences between them may c...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00374-17
更新日期:2017-10-18 00:00:00
abstract::Yersinia pestis causes bubonic, pneumonic, and septicemic plague, diseases that are rapidly lethal to most mammals, including humans. Plague develops as a consequence of bacterial neutralization of the host's innate immune response, which permits uncontrolled growth and causes the systemic hyperactivation of the infla...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00570-17
更新日期:2017-10-18 00:00:00
abstract::Tularemia is caused by the Gram-negative bacterial pathogen Francisella tularensis Infection of macrophages and their subsequent death are believed to play important roles in the progression of disease. Because complement is a particularly effective opsonin for Francisella, we asked whether complement-dependent uptake...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00424-17
更新日期:2017-09-20 00:00:00
abstract::Gram-negative bacterial pathogens utilize virulence-associated secretion systems to inject, or translocate, effector proteins into host cells to manipulate cellular processes and promote bacterial replication. However, translocated bacterial products are sensed by nucleotide binding domain and leucine-rich repeat-cont...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00778-16
更新日期:2017-09-20 00:00:00
abstract::Ecto-5'-nucleotidase (CD73) is expressed abundantly on the apical surface of intestinal epithelial cells (IECs) and functions as the terminal enzyme in the generation of extracellular adenosine. Previous work demonstrated that adenosine signaling in IECs results in a number of tissue-protective effects during inflamma...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01022-16
更新日期:2017-09-20 00:00:00
abstract::The obligate intracellular parasite Toxoplasma gondii can actively infect any nucleated cell type, including cells from the immune system. The rapid transfer of T. gondii from infected dendritic cells to effector natural killer (NK) cells may contribute to the parasite's sequestration and shielding from immune recogni...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00069-17
更新日期:2017-09-20 00:00:00
abstract::Exoenzyme Y (ExoY) is a type III secretion system effector found in 90% of the Pseudomonas aeruginosa isolates. Although it is known that ExoY is a soluble nucleotidyl cyclase that increases the cytoplasmic levels of nucleoside 3',5'-cyclic monophosphates (cNMPs) to mediate endothelial Tau phosphorylation and permeabi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00239-17
更新日期:2017-08-18 00:00:00
abstract::Candida albicans is a ubiquitous mucosal commensal that is normally prevented from causing acute or chronic invasive disease. Neutrophils contribute to protection in oral infection but exacerbate vulvovaginal candidiasis. To dissect the role of neutrophils during mucosal candidiasis, we took advantage of a new, transp...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00276-17
更新日期:2017-08-18 00:00:00
abstract::The type III secretion system (T3SS) plays a crucial role in the pathogenesis of many Gram-negative bacteria, including Edwardsiella tarda, an important fish pathogen. Within the E. tarda T3SS, there are three proteins (EsaB/EsaL/EsaM) that are homologous to proteins present in many other bacteria, including SpiC/SsaL...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00322-17
更新日期:2017-08-18 00:00:00
abstract::Artesunate remains the mainstay of treatment for cerebral malaria, but it is less effective in later stages of disease when the host inflammatory response and blood-brain barrier integrity dictate clinical outcomes. Nitric oxide (NO) is an important regulator of inflammation and microvascular integrity, and impaired N...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00371-17
更新日期:2017-08-18 00:00:00
abstract::The bacterial pathogen Listeria monocytogenes causes foodborne systemic disease in pregnant women, which can lead to preterm labor, stillbirth, or severe neonatal disease. Colonization of the maternal decidua appears to be an initial step in the maternal component of the disease as well as bacterial transmission to th...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00153-17
更新日期:2017-07-19 00:00:00
abstract::Aeromonas salmonicida causes furunculosis in salmonids and is a threat to Atlantic salmon aquaculture. The epithelial surfaces that the pathogen colonizes are covered by a mucus layer predominantly comprised of secreted mucins. By using mass spectrometry to identify mucin glycan structures with and without enzymatic r...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00189-17
更新日期:2017-07-19 00:00:00
abstract::Methicillin-resistant Staphylococcus aureus (MRSA) is responsible for large numbers of postsurgical nosocomial infections across the United States and worldwide. Propofol anesthesia is widely used in surgery and in intensive care units, and recent evidence indicates that even brief exposure to propofol can substantial...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00097-17
更新日期:2017-06-20 00:00:00
abstract::Coxiella burnetii is the causative agent of Q fever, a zoonotic disease that threatens both human and animal health. Due to the paucity of experimental animal models, little is known about how host factors interface with bacterial components and affect pathogenesis. Here, we used Drosophila melanogaster, in conjunctio...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00218-17
更新日期:2017-06-20 00:00:00
abstract::Most Helicobacter pylori strains express the BabA adhesin, which binds to ABO/Leb blood group antigens on gastric mucin and epithelial cells and is found more commonly in strains that cause peptic ulcers or gastric cancer, rather than asymptomatic infection. We and others have previously reported that in mice, gerbils...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00094-17
更新日期:2017-05-23 00:00:00
abstract::Toxoplasma gondii and Neospora caninum (both Apicomplexa) are closely related cyst-forming coccidian parasites that differ significantly in their host ranges and ability to cause disease. Unlike eutherian mammals, Australian marsupials (metatherian mammals) have long been thought to be highly susceptible to toxoplasmo...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00173-17
更新日期:2017-05-23 00:00:00
abstract::Type II secretion (T2S) is one means by which Gram-negative pathogens secrete proteins into the extracellular milieu and/or host organisms. Based upon recent genome sequencing, it is clear that T2S is largely restricted to the Proteobacteria, occurring in many, but not all, genera in the Alphaproteobacteria, Betaprote...
journal_title:Infection and immunity
pub_type: 杂志文章,评审
doi:10.1128/IAI.00014-17
更新日期:2017-04-21 00:00:00
abstract::Pneumocystis pneumonia (PcP) is a life-threatening infection that affects immunocompromised individuals. Nearly half of all PcP cases occur in those prescribed effective chemoprophylaxis, suggesting that additional preventive methods are needed. To this end, we have identified a unique mouse Pneumocystis surface prote...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00850-16
更新日期:2017-03-23 00:00:00
abstract::Salmonella enterica serovar Typhi is a human-restricted Gram-negative bacterial pathogen responsible for causing an estimated 27 million cases of typhoid fever annually, leading to 217,000 deaths, and current vaccines do not offer full protection. The O-antigen side chain of the lipopolysaccharide is an immunodominant...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01021-16
更新日期:2017-03-23 00:00:00
abstract::Previously, we reported that mutants of Legionella pneumophila lacking a type II secretion (T2S) system elicit higher levels of cytokines (e.g., interleukin-6 [IL-6]) following infection of U937 cells, a human macrophage-like cell line. We now show that this effect of T2S is also manifest upon infection of human THP-1...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00897-16
更新日期:2017-03-23 00:00:00
abstract::Staphylococcus aureus is an important opportunistic pathogen and is the etiological agent of many hospital- and community-acquired infections. The golden pigment, staphyloxanthin, of S. aureus colonies distinguishes it from other staphylococci and related Gram-positive cocci. Staphyloxanthin is the product of a series...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00838-16
更新日期:2017-01-26 00:00:00
abstract::Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection (STI) gonorrhea, is a growing public health threat for which a vaccine is urgently needed. We characterized the functional role of the gonococcal MetQ protein, which is the methionine binding component of an ABC transporter system, and as...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00898-16
更新日期:2017-01-26 00:00:00
abstract::Interleukin-10 (IL-10)-producing B cells (B10 cells) play a critical role in the immune system balance by negatively regulating inflammatory responses. This study was conducted to determine the effect of local B10 cell induction on periodontal inflammation and bone loss in ligature-induced experimental periodontitis i...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00645-16
更新日期:2016-12-29 00:00:00
abstract::Lyme disease (LD), the most prevalent tick-borne illness in North America, is caused by Borrelia burgdorferi The long-term survival of B. burgdorferi spirochetes in the mammalian host is achieved though VlsE-mediated antigenic variation. It is mathematically predicted that a highly variable surface antigen prolongs ba...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00890-16
更新日期:2016-12-29 00:00:00
abstract::Vibrio cholerae is the causative bacteria of the diarrheal disease cholera, but it also persists in aquatic environments, where it displays an expression profile that is distinct from that during infection. Upon entry into the host, a tightly regulated circuit coordinates the induction of two major virulence factors: ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00707-16
更新日期:2016-12-29 00:00:00
abstract::Scrub typhus is a potentially lethal infection that is caused by the obligate intracellular bacterium Orientia tsutsugamushi The roles of Toll-like receptor 2 (TLR2) and TLR4 in innate recognition of O. tsutsugamushi have not been elucidated. By overexpression of TLR2 or TLR4 in HEK293 cells, we demonstrated that TLR2...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00185-16
更新日期:2016-11-18 00:00:00
abstract::Filifactor alocis is a recently recognized periodontal pathogen; however, little is known regarding its interactions with the immune system. As the first-responder phagocytic cells, neutrophils are recruited in large numbers to the periodontal pocket, where they play a crucial role in the innate defense of the periodo...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00496-16
更新日期:2016-11-18 00:00:00
abstract::Chronic pulmonary infection with Pseudomonas aeruginosa is a feature of cystic fibrosis (CF) and other chronic lung diseases. Cytokines of the interleukin-17 (IL-17) family have been proposed as important in the host response to P. aeruginosa infection through their role in augmenting antibacterial immune responses, a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00717-16
更新日期:2016-11-18 00:00:00